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Original Research |

Goodpasture's Syndrome Associated with Influenza A2 Virus Infection

[+] Article, Author, and Disclosure Information

Supported in part by contract PH-43-68-621, U.S. Public Health Service, Washington, D.C.

▸Requests for reprints should be addressed to Curtis B. Wilson, M.D., Scripps Clinic and Research Foundation, 476 Prospect St., La Jolla, Calif. 92037

La Jolla, California, and Iowa City, Iowa

Ann Intern Med. 1972;76(1):91-94. doi:10.7326/0003-4819-76-1-91
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A woman developed severe hemoptysis and glomerulonephritis (Goodpasture's syndrome) in association with an apparent influenza A2 virus infection. The proliferative glomerular lesion contained immunofluorescent deposits of immunoglobulin and complement in a linear pattern along the glomerular basement membrane (GBM), suggesting the presence of anti-GBM antibodies. The pulmonary and renal functional abnormalities rapidly diminished and were absent on examination 5 years after the original illness. This suggested that the response was short-lived and may have been triggered by a transient, virally associated antigenic stimulus.





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