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Metformin and B-12 Malabsorption

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Columbia University College of Physicians & Surgeons, and Bronx Veterans Administration Hospital, New York, N.Y.

Ann Intern Med. 1972;76(1):140-141. doi:10.7326/0003-4819-76-1-140
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Several drugs, including certain chemotherapeutic agents (methotrexate), antimalarials (pyrimethamine), diuretics (triamterene), protozoacides (pentamidine isethionate), antibacterials (trimethoprim), anticonvulsants (diphenylhydantoin sodium), sedatives (barbiturates), oral contraceptives, antituberculous agents (cycloserine, para-aminosalicylic acid), and colchicine (for gout), may produce intestinal malabsorption of vitamin B-12 or of folic acid, or both (1). The latest culprit to be added to the ranks of such drugs is metformin (2), a member of the biguanide group of oral hypoglycemic agents used to treat obese, mild-diabetes patients, in whom they are alleged to favor weight loss (3).

Any drug capable of producing intestinal malabsorption may potentially produce malabsorption of vitamin


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