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Oozing and Bruising Due to Abnormal Platelet Function (Thrombocytopathia): A Family Study of the Syndrome

STANLEY ZUCKER, M.D.; C. HAROLD MIELKE JR., M.D.; JOHN R. DUROCHER, M.D.; and WILLIAM H. CROSBY, M.D.
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▸Requests for reprints should be addressed to Stanley Zucker, M.D., Department of Medicine, Veterans Administration Hospital, Northport, N.Y. 11768.


Boston, Massachusetts


Ann Intern Med. 1972;76(5):725-731. doi:10.7326/0003-4819-76-5-725
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This report describes 6 unrelated patients with mild bleeding disorders caused by abnormalities of platelet function. This syndrome has its onset in childhood and has one or more of these characteristics: easy bruising, spontaneous bleeding from mucosal membranes, excessive bleeding after minor or major surgery, and menorrhagia. Coagulation tests in these patients showed a prolonged bleeding time and a delayed and diminished platelet aggregation response to epinephrine and collagen. The platelet count, platelet adhesiveness, platelet factor-3 release, and factor VIII activity were usually normal. Pedigree studies suggested an autosomal-dominant mode of inheritance. An experimental trial of prednisone therapy in five patients resulted in significant improvement in the bleeding time, yet platelet aggregation test results were unaltered.

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