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The Differential Diagnosis of Hypercalcemia

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Metabolic Endocrine Laboratory
Department of Medicine
Montefiore Hospital and Medical Center
Albert Einstein College of Medicine
Bronx, N.Y.

Ann Intern Med. 1972;76(5):825-826. doi:10.7326/0003-4819-76-5-825_2
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The differential diagnosis of hypercalcemia may be a difficult problem for the practicing physician and one with which he is confronted more frequently now that multichannel analysis of serum is widely practiced and more cases of hypercalcemia, often asymptomatic, are uncovered.

The major problem has been the differentiation of hyperparathyroidism from other causes of hypercalcemia. The diagnostic maneuvers have included various indexes of phosphate excretion and cortisone suppression tests, and have not always separated the two categories. Recently described relationships among serum calcium levels, acid-base blood variables, and the degree of parathyroid hormone activity seem to provide a new avenue




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