0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Diagnosis and Localization in Primary Aldosteronism

RICHARD HORTON, M.D.; and ETHYL FINCK, M.D.
[+] Article and Author Information

Supported by grants HE-13476 and G CRC RR-43, National Institutes of Health, Bethesda, Md.

Presented in part 27 January 1971 at the Western Association of Physicians meeting, Carmel, Calif.

▸Requests for reprints should be addressed to Richard Horton, M.D., University of Southern California School of Medicine, 2025 Zonal Avenue, Los Angeles, Calif. 90033.


Ann Intern Med. 1972;76(6):885-890. doi:10.7326/0003-4819-76-6-885
Text Size: A A A

Aldosterone in peripheral and adrenal vein plasma was measured in 21 patients highly suspect for primary aldosteronism. Peripheral and adrenal vein aldosterone levels were measured by a sensitive, accurate radioimmunoassay. Base-line and postfludrocortisone plasma aldosterone values were elevated in all patients while they were supine, with values ranging above normal to very high levels. Adrenal venograms were done in sixteen patients, and a positive radiologic interpretation was made in three fourths. The adrenalvein aldosterone values, however, were diagnostic in all patients. Primary aldosteronism, due to an adenoma, was shown by high levels of aldosterone on the side of the lesion and much lower levels, usually approaching peripheral, on the unaffected side. Aldosteronism due to bilateral hyperplasia appears to be associated with symmetrically elevated levels. These studies suggest that adrenal vein analysis of aldosterone is the most important part of the venogram procedure for localization and diagnosis in primary aldosteronism.

Topics

conn adenoma

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)