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Preoperative Lateralisation of Aldosterone-Producing Tumours in Primary Aldosteronism

BRUCE A. SCOGGINS, Ph.D.; CATHERINE J. ODDIE, M.Sc.; WILLIAM S. C. HARE, M.D.; and JOHN P. COGHLAN, Ph.D.
[+] Article and Author Information

Supported in part by the National Health and Medical Research Council of Australia and the National Heart Foundation of Australia, Canberra, ACT; grant HE 11580-04, U.S. Public Health Service, Washington, D.C.; and a grant-in-aid from G. D. Searle (Australia) Pty. Ltd.

Presented in part August 1970, 13th Australian Endocrine Society Annual Meeting, Melbourne.

▸Requests for reprints should be addressed to Bruce A. Scoggins, Ph.D., Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria 3052, Australia.


Ann Intern Med. 1972;76(6):891-897. doi:10.7326/0003-4819-76-6-391
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A technique based on measurement of aldosterone in peripheral and left-adrenal venous plasma is described for the preoperative lateralisation of aldosterone-producing adenomas of the adrenal. It has been used in conjunction with adrenal phlebography. The procedure has been evaluated in 11 patients with primary aldosteronism; 10 were predicted accurately, 7 having an adenoma on the left, and 3 on the right. In the one patient about whom a decision could not be made, bilateral adrenal adenomas were found at surgery.

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