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Sickle-Cell Anemia: The Known and the Unknown

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Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Md.

Ann Intern Med. 1972;77(1):148-149. doi:10.7326/0003-4819-77-1-148
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Sickle-cell anemia has become a topic of intense public interest; newspaper columnists, college students, baseball players, and Marcus Welby have devoted attention to it. The Congress has also paid attention, and it seems possible that more than 100 million dollars will be appropriated to "fight" this disease. Contrary to public opinion, research in this area has not been lacking in the past, although the anticipated influx of money has awakened much new interest. We now understand more about the pathogenesis of the illness, from molecule to man, than we do about that of almost any other disease (1). Like many


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