0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Cobalt Test for the Detection of Iron Deficiency Anemia

LESLIE S. VALBERG, M.D., F.A.C.P.; JANET SORBIE, M.B.; WILLIAM E. N. CORBETT, M.D.; and JOHN LUDWIG
[+] Article and Author Information

Supported in part by a grant from the Medical Research Council, Ottawa, Canada.

▸Requests for reprints should be addressed to L. S. Valberg, M.D., Etherington Hall, Queen's University, Kingston, Ontario, Canada.


Kingston, Ontario,Canada


Ann Intern Med. 1972;77(2):181-187. doi:10.7326/0003-4819-77-2-181
Text Size: A A A

A test to detect iron deficiency anemia is based on the 6-hour urinary excretion of oral 57Co. The mean excretion in 25 healthy control subjects 31 to 75 years of age with stainable iron in the marrow was 7.3% (range, 4% to 11%). Twenty-six patients with iron deficiency anemia excreted more than 12% of the dose, whereas 30 patients with anemia from other causes excreted less than 11%. Cobalt excretion was also markedly increased in subjects who had iron deficiency without anemia and moderately increased in nonanemic subjects with recent blood loss, even when stainable iron was present in the marrow. The cobalt test does not supplant simpler diagnostic techniques, but it does provide the clinician with a practical alternative to bone marrow aspiration in the differential diagnosis of iron deficiency anemia. It is particularly applicable in mild iron deficiency anemia and in differentiating iron deficency anemia from anemia due to other causes.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Topic Collections
PubMed Articles

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)