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Eosinophilic Leukemia with Fibrosing Endocarditis and Short Y Chromosome

LTC EUGENE P. FLANNERY, M.D.; LTC DONALD E. DILLON, M.D., F.A.C.P.; COL MAHLON V. R. FREEMAN, M.D.; CPT JAMES D. LEVY, M.D.; LTC UMBERTO D'AMBROSIO, M.D.; and LTC JULIUS L. BEDYNEK, M.D.
[+] Article and Author Information

▸Requests for reprints should be addressed to LTC Eugene P. Flannery, M.D., Chief, Hematology Section, Letterman General Hospital, Presidio of San Francisco, Calif. 94129.


Washington, D.C.


Ann Intern Med. 1972;77(2):223-228. doi:10.7326/0003-4819-77-2-223
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Hematologic data in previous cases of eosinophilia with fibrosing endocarditis have been too limited to firmly establish a relation to the myeloproliferative disorders. A patient with the typical clinical and autopsy features of Loeffler's endocarditis also had an equally definite eosinophilic myeloproliferative disorder. The neutrophil alkaline phosphatase score, peripheral blood basophilia, serum vitamin B12, B12-binding proteins, serum muramidase, peripheral blood smear, and bone marrow and autopsy findings were all consistent with the neutrophilic type of chronic granulocytic leukemia. A presumed Philadelphia chromosome (Ph1) later proved to be a short Y chromosome, which indicates the need for physicians to be alert for its presence in males with apparent Ph1 chromosome.

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