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Crystalglobulinemia

JAY GROSSMAN, M.D.; GEORGE N. ABRAHAM, M.D.; JOHN P. LEDDY, M.D.; and JOHN L. CONDEMI, M.D., F.A.C.P.
[+] Article and Author Information

Supported in part by training grant AI-00028 and service research grant RR-00044, U.S. Public Health Service, Washington, D.C., and the Monroe County Chapter of The Arthritis Foundation, Rochester, N.Y.

Presented in part at the Upstate New York Regional Meeting of The American College of Physicians, 15 October 1971.

▸ Requests for reprints should be addressed to John J. Condemi, M.D., Department of Medicine, University of Rochester School of Medicine and Dentistry, 260 Crittenden Blvd., Rochester, N.Y. 14642.


Rochester, New York


Ann Intern Med. 1972;77(3):395-400. doi:10.7326/0003-4819-77-3-395
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A cryoprotein consisting of spontaneously formed crystals of gamma globulin (IgG3K) has been found in the serum of a 54-year-old woman who has had repeated episodes of widespread purpura and necrotic cutaneous ulcerations. No renal disease or involvement of other organ systems have been observed. Analyses of the patient's serum showed microscopic crystals of gamma globulin comprising at times almost 50% of her serum volume when cooled to 4 °C. Treatment with corticoids and plasmapheresis has been successful in controlling the manifestations of her disease.

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