The full content of Annals is available to subscribers

Subscribe/Learn More  >
Original Research |

Circulating Anticoagulants Against Factors IX and XI in Systemic Lupus Erythematosus

[+] Article, Author, and Disclosure Information

Supported in part by training grant HE 05316-11 and research grant HE 09057-08, U.S. Public Health Service, Washington, D.C., a research grant from the American Heart Association, New York, N.Y., and Veterans Administration Research funds, Veterans Administration Hospital, West Haven, Conn.

▸Requests for reprints should be addressed to Oswaldo Castro, M.D., Department of Internal Medicine, Yale University School of Medicine, 333 Cedar St., New Haven, Conn. 06510.

New Haven and West Haven, Connecticut

Ann Intern Med. 1972;77(4):543-548. doi:10.7326/0003-4819-77-4-543
Text Size: A A A

In four patients with systemic lupus erythematosus and unusual circulating anticoagulants the partial thromboplastin time of normal plasma was prolonged by the patient's plasma, but the prothrombin time was normal. Low plasma levels of factor IX in one case and of factor XI in two cases were the only coagulation abnormalities, suggesting that the anticoagulant was directed against these factors. In the fourth patient, assay values of factors V, VIII, IX, and X were not low enough to explain the prolonged partial thromboplastin time. Adequate contact product was found, but the patient's plasma had anticoagulant activity against her own and normal contact product. This interfered with assays of factors XI and XII; we believe that in this patient the anticoagulant was directed against activated factor XI. In two cases there was significant bleeding. Treatment with prednisone and immunosuppressive agents resulted in disappearance of the clotting abnormalities.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Journal Club
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.