0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Posttransfusion Hepatitis After Exclusion of Commercial and Hepatitis-B Antigen-Positive Donors

HARVEY J. ALTER, M.D.; PAUL V. HOLLAND, M.D.; ROBERT H. PURCELL, M.D.; JERROLD J. LANDER, M.D.; STEPHEN M. FEINSTONE, M.D.; ANDREW G. MORROW, M.D.; and PAUL J. SCHMIDT, M.D.
[+] Article and Author Information

Presented in part at The Symposium on Australia Antigen, American Society of Microbiology, Philadelphia, November 1971.

▸Requests for reprints should be addressed to Harvey J. Alter, M.D., Blood Bank Department, Clinical Center, National Institutes of Health, Bethesda, Md.


Bethesda, Maryland


Ann Intern Med. 1972;77(5):691-699. doi:10.7326/0003-4819-77-5-691
Text Size: A A A

In a prospective study the exclusion of commercial blood donors and donors positive for hepatitis-B antigen (HBAg) resulted in a hepatitis frequency of only 3.7 cases/1000 units transfused. Residual posttransfusion hepatitis was caused by at least two viruses. Four of 10 cases were short incubation, HBAg negative; six cases were long incubation, HBAg positive. One patient had both diseases in sequence. Some cases of HBAg-positive hepatitis occurred despite the fact that patients received only blood that was HBAg negative by counterelectrophoresis; current tests for HBAg, including radioimmunoassay, cannot detect all donors capable of transmitting HBAg-positive hepatitis. The presence of anti-HBAg in donor blood was common and did not correlate with posttransfusion hepatitis; donors with anti-HBAg should not be excluded.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)