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Serum Gastrin Levels in Primary Hypogammaglobulinemia and Pernicious Anemia: Studies in Adults

WILLIAM S. HUGHES, M.D.; FRANK P. BROOKS, M.D.; and HAROLD O. CONN, M.D.
[+] Article and Author Information

Supported in part by grants PH-AM14663-01 and TO1 AM5462-06 from the National Institutes of Health, Bethesda, Md.; Veterans Administration Research Service, Washington, D.C.; The Stratfield Fund; and the Irwin Stratburger Memorial Fund.

Presented in part 27 January 1972 before the Gastroenterology Section of the American Federation for Clinical Research Southern Section, New Orleans, La.

▸Requests for reprints should be addressed to William S. Hughes, M.D., Department of Internal Medicine, University of Texas Medical Branch, Galveston, Tex. 77550.


Philadelphia, Pennsylvania, Galveston, Texas, and West Haven, Connecticut


Ann Intern Med. 1972;77(5):746-750. doi:10.7326/0003-4819-77-5-746
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Fasting serum gastrin levels were measured in 12 adults with primary hypogammaglobulinemia, 15 patients with primary pernicious anemia, and control subjects. Five of the patients with primary hypogammaglobulinemia had pernicious anemia. The fasting serum gastrin level in patients with primary hypogammaglobulinemia and pernicious anemia (74 ± 20 pg/ml [mean ± SE]) was significantly lower (P < 0.001) than the level in patients with primary pernicious anemia (1336 ± 189 pg/ml). The gastrin levels in hypogammaglobulinemic patients with pernicious anemia (74 ± 20 pg/ml) and without pernicious anemia (72 ± 12 pg/ml) were similar to the level in normal age-matched (41 to 50 years) control subjects (89 ± 11 pg/ml). The new finding of normal fasting serum gastrin levels in patients with hypogammaglobulinemia and pernicious anemia suggests that, in contrast to the gastric lesion in primary pernicious anemia, the gastric lesion in primary hypogammaglobulinemia involves the gastrin-producing cells of the gastric antrum as well as the parietal cells of the gastric body and fundus.

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