0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Treatment of Lupus Nephritis with Prednisone and Combined Prednisone and Azathioprine

JAMES V. DONADIO JR., M.D., F.A.C.P.; KEITH E. HOLLEY, M.D.; RICHARD D. WAGONER, M.D., F.A.C.P.; RICHARD H. FERGUSON, M.D., F.A.C.P.; and FREDERIC C. McDUFFIE, M.D., F.A.C.P.
[+] Article and Author Information

Supported in part by a grant from the Mayo Foundation, Rochester, Minn.

▸Requests for reprints should be addressed to J. V. Donadio, Jr., M.D., Division of Nephrology, Mayo Clinic, Rochester, Minn. 55901.


Rochester, Minnesota


Ann Intern Med. 1972;77(6):829-835. doi:10.7326/0003-4819-77-6-829
Text Size: A A A

The relative effectiveness of high-dose prednisone (group A) was compared with the same regimen plus azathioprine (group B) for the treatment of lupus nephritis of mild or moderate severity over 6 months. Nephritis activity was graded by renal biopsy specimens; biopsies were repeated and rescored at 6 months. There was significant improvement in all patients of both groups. Creatinine clearance, urinary sediment abnormalities, proteinuria, hypocomplementemia, and high titers of antinuclear antibodies showed improvement in most patients, but none correlated completely with the improvement in renal biopsy scores. High doses of corticosteroids are effective in the short-term treatment of mild or moderately severe lupus nephritis; the addition of azathioprine over the short term does not improve the results. Two patients with severe lupus nephritis who were treated with steroids alone died within 2 months, so that a possible beneficial effect of added azathioprine in severe, advanced disease cannot be excluded.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Journal Club
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)