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Rheumatoid Pericarditis: Report of 17 Cases Diagnosed Clinically

ALEJANDRO E. FRANCO, M.D.; HAROLD D. LEVINE, M.D., F.A.C.P.; and ARTHUR P. HALL, M.D.
[+] Article and Author Information

Dr. Franco was supported in part by grant AM 5076, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Md.

Presented in part 14 June 1971, Annual Scientific Meeting of the American Rheumatism Association, New York, N.Y.

▸Requests for reprints should be addressed to A. E. Franco, M.D., Clinical Pharmacology Unit, School of Medicine, Medical Science Campus, San Juan, P.R. 00936.


Boston, Massachusetts


Ann Intern Med. 1972;77(6):837-844. doi:10.7326/0003-4819-77-6-837
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Seventeen patients with rheumatoid pericarditis, diagnosed clinically, are compared with 41 cases reported in the literature and with 85 control patients with rheumatoid arthritis but without pericarditis. Rheumatoid pericarditis occurred in patients with definite or classical rheumatoid arthritis. Rheumatoid factor, present in 93% of the patients tested, was statistically commoner than in the control group. Subcutaneous nodules were present in 47%. The presenting complaints were left-sided chest pain (59%) and symptoms of congestive heart failure (18%). A pericardial friction rub was detected in 65%. All patients had cardiomegaly, as seen by X ray, accompanied by pleural effusion in 65%. A low sugar concentration in the pericardial fluid, elevated lactic dehydrogenase and gamma globulin levels, and, probably, a low complement value indicate rheumatoid arthritis as the most probable cause of the effusion. Over one third of the pericarditis patients eventually required pericardiectomy or died of their disease.

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[Cholesterol crystals pericarditis in a patient with rheumatoid arthritis.] Arch Cardiol Mex Published online Sep 17, 2014.;
[Pleuro-pericarditis developed under a leflunomide therapy.] Rev Pneumol Clin Published online Nov 20, 2014.;
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