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Antibiotic Management in Patients with Chronic Bronchitis and Emphysema

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University of Arizona, College of Medicine, Tucson, Ariz.

Ann Intern Med. 1972;77(6):993-995. doi:10.7326/0003-4819-77-6-993
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Bronchopulmonary infection has been suspected of playing various roles in the development and course of chronic bronchitis and emphysema. As discussed below, there are theoretical reasons to suspect that infection might be an important causative factor. Clinical observations suggest that it does at least accelerate the course of these diseases. And without doubt, purulent exacerbations of bronchitis are major causes of excess morbidity and mortality in patients with these obstructive lung disorders.

Recognition of the association between severe hereditary alpha1-antitrypsin deficiency and pulmonary emphysema (1) has rekindled interest in the possible role of bronchopulmonary infection in the development of this


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