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Hyperbaric Oxygen Therapy: Size of Infarct Determines Therapeutic Efficacy

STANLEY C. GLAUSER, M.D., Ph.D.; and ELINOR M. GLAUSER, M.D.
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▸Requests for reprints should be addressed to Stanley C. Glauser, M.D., Department of Pharmacology, School of Medicine, Temple University, 3400 N. Broad St., Philadelphia, Pa. 19140.


Philadelphia, Pennsylvania


Ann Intern Med. 1973;78(1):77-80. doi:10.7326/0003-4819-78-1-77
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There are differing reports of the efficiency of hyperbaric oxygen therapy for thrombotic and embolic states. An analysis of the volume of tissue necrotized as a function of the radius of tissue originally supplied with oxygen by the occluded vessel was made. The volume of necrosis increases rapidly as the cube of the original radius. The volume of tissue saved by breathing 100% oxygen at three atmospheres increases more slowly, as the square of the original radius. Thus the percent of tissue saved varies according to the reciprocal of the original radius, and any phenomena that produce multiple small necrotic areas will respond more favorably to hyperbaric oxygen therapy than any phenomena that produce one large volume of necrosis.

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