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Effect of Induced Fever on Sulfobromophthalein Kinetics in Man

TERRENCE F. BLASCHKE, M.D.; RONALD J. ELIN, M.D., Ph.D.; PAUL D. BERK, M.D., F.A.C.P.; CHULL S. SONG, M.D., Ph.D., F.A.C.P.; and SHELDON M. WOLFF, M.D., F.A.C.P.
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▸Address reprint requests to Dr. Paul D. Berk, National Cancer Institute, National Institutes of Health, Building 10, Room 4N117, Bethesda, Md. 20014.


Bethesda, Maryland


Ann Intern Med. 1973;78(2):221-226. doi:10.7326/0003-4819-78-2-221
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The effect of fever induced by endotoxin or etiocholanolone on sulfobromophthalein (BSP) kinetics was examined in 20 healthy volunteers by analyzing the plasma disappearance curves obtained after a single injection of 5.0 mg/kg body weight of BSP during the fever. In addition to 45-minute retention, BSP clearances, the values for the parameters of a compartmental model of BSP metabolism, and relative hepatic BSP storage capacity were calculated by computer from the experimental curves. Although only 9 of the 20 fever volunteers had abnormal BSP retention at 45 minutes, all pyrogen-treated subjects had significant changes in values for the compartmental parameters. The largest changes were in the values for BSP reflux from liver to plasma, which increased to 587% of control values, and for relative hepatic BSP storage capacity, which fell by 46%. These results indicate that caution must be used in interpreting the BSP test in patients who are even mildly febrile.

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