0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Brief Communications |

The Clinical Significance of Hypouricemia

C. MICHAEL RAMSDELL, M.D.; and WILLIAM N. KELLEY, M.D., F.A.C.P.
[+] Article and Author Information

Supported in part by training grant AM05620 from the U.S. Public Health Service, Washington, D.C., and by grant RR-30 from the General Clinical Research Centers Program of the Division of Research Resources, National Institutes of Health, Bethesda, Md.

▸Requests for reprints should be addressed to William N. Kelley, M.D., P.O. Box 3211, Duke University Medical Center, Durham, N.C. 27710.


Durham, North Carolina


Ann Intern Med. 1973;78(2):239-242. doi:10.7326/0003-4819-78-2-239
Text Size: A A A

Hypouricemia (serum urate, < 2 mg/100 ml) was noted in 0.97% of 6629 consecutive serum urate measurements done at two large hospitals. In two thirds of the hypouricemic patients drugs, including aspirin, allopurinol, X-ray contrast agents, and glyceryl guaiacholate, seemed to be responsible for the decreased serum urate concentration; disseminated carcinomas were noted in nine more hypouricemic patients. In many of these subjects an alteration in the renal tubular handling of uric acid seemed to cause the development of hypouricemia. Poor dietary intake of protein and purines and hypo-osmolality were common findings that may have contributed to the development of hypouricemia in some patients. Although hypouricemia has been reported as a common manifestation of several relatively rare diseases, these illnesses are unusual causes of the hypouricemia found in a general hospital population.

Topics

hypouricemia

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)