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Severe Allergic Pneumonitis from Hydrochlorothiazide

CLAUDE BEAUDRY, M.D., F.R.C.P. (C); and LOUIS LAPLANTE, M.D., F.R.C.P. (C)
[+] Article and Author Information

▸Requests for reprints should be addressed to Claude Beaudry, M.D., Maisonneuve Hospital, 5415 Blvd. de l'Assomption, Montreal 410, Quebec, Canada.


Montreal, Quebec, Canada


Ann Intern Med. 1973;78(2):251-253. doi:10.7326/0003-4819-78-2-251
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A 32-year-old white man with essential hypertension presented with three episodes of acute and severe pulmonary allergic pneumonitis on ingestion of one 50-mg tablet of hydrochlorothiazide. The third episode, noticed during a challenge test, was similar to the previous two episodes. To our knowledge this is the third case of severe allergic pneumonitis secondary to hydrochlorothiazide and the first in which a challenge test was done.

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