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Hypercalcemia in Reticulum Cell Sarcoma Without Hyperparathyroidism or Skeletal Metastases

FREDERICK R. SINGER, M.D.; DAVID POWELL, M.R.C.P.; CEDRIC MINKIN, Ph.D.; JOHN E. BETHUNE, M.D., F.A.C.P.; ARNOLD BRICKMAN, M.D.; and JACK W. COBURN, M.D., F.A.C.P.
[+] Article and Author Information

Dr. Singer is a Clinical Investigator of the Veterans Administration, Dr. Brickman is a Research and Education Associate of the Veterans Administration, and Dr. Minkin is a U.S. Public Health Service Research Career Development Awardee.

Supported in part by grants AM-5383, AM-05072, AM-04501, AM-11794, DE-02849 of the U.S.P.H.S., and grants from the John A. Hartford Foundation and the Gebbie Foundation.

▸Requests for reprints should be addressed to Dr. Frederick R. Singer, Wadsworth Veterans Administration Hospital, Wilshire and Sawtelle Blvds., Los Angeles, CA 90073.


Los Angeles, California, and Boston, Massachusetts


Ann Intern Med. 1973;78(3):365-369. doi:10.7326/0003-4819-78-3-365
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A patient with reticulum cell sarcoma and hypercalcemia had a remission of the hypercalcemia after localized radiation therapy. The tumor and hypercalcemia recurred 2 years later. Examination of blood and tumor extract from the patient by a sensitive radioimmunoassay for parathyroid hormone failed to detect the hormone. Tumor extract raised serum calcium when injected into parathyroidectomized mice and caused release of 45Ca from mouse calvaria in vitro. At autopsy the patient had four normal parathyroid glands and no skeletal metastases. The humoral agent responsible for the hypercalcemia in this patient remains to be elucidated.

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