The full content of Annals is available to subscribers

Subscribe/Learn More  >
Brief Communications |

Hypouricemia due to Renal Uricosuria: A Case Study

[+] Article and Author Information

▸Requests for reprints should be addressed to A. K. Khachadurian, M.D., Clinical Research Center, The Children's Memorial Hospital, 2300 Children's Plaza, Chicago, IL 60614.

Ann Intern Med. 1973;78(4):547-550. doi:10.7326/0003-4819-78-4-547
Text Size: A A A

A 57-year-old healthy man had a plasma uric acid level of 0.2 to 0.58 mg/100 ml. The 24-hour urinary urate excretion was normal, at 797 mg. Urate clearance was 48% higher than endogenous creatinine clearance. Urinary xanthine and hypoxanthine levels were at the upper limit of normal. There was no evidence of phosphaturia, glucosuria, or aminoaciduria. A 10-year-old son of his maternal cousin had a plasma urate level of 1.2 mg/100 ml and a urate clearance equal to 42% of endogenous creatinine clearance. The findings in this subject could be accounted for by an isolated defect of tubular urate reabsorption or a tubular mechanism for urate secretion.


kidney ; hypouricemia





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.