The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Adverse Reactions to Duck Embryo Rabies Vaccine: Range and Incidence

R. H. RUBIN, M.D.; M. A. W. HATTWICK, M.D.; S. JONES, M.D.; M. B. GREGG, M.D.; and V. D. SCHWARTZ, M.D.
[+] Article, Author, and Disclosure Information

▸Requests for reprints should be addressed to Michael B. Gregg, M.D., Chief, Viral Diseases Branch, Epidemiology Program, Center for Disease Control, Atlanta, GA 30333.

Atlanta, Georgia

Ann Intern Med. 1973;78(5):643-649. doi:10.7326/0003-4819-78-5-643
Text Size: A A A

Approximately 424 000 persons received duck embryo rabies vaccine between 1958 and 1971, with the following serious reactions being voluntarily reported: 22 cases of anaphylaxis, 11 of abdominal pain associated with nausea and vomiting, 5 of cranial or peripheral neuropathy, 4 of transverse myelitis, 2 of nonfatal encephalopathy, 2 of fatal encephalitis, and 1 of thrombocytopenic purpura. The only reported deaths occurred in individuals who may have died of other causes—for example, rabies itself. To determine the true incidence of reactions to the vaccine, prospective studies were carried out: of 1679 persons receiving preexposure prophylaxis, 67% developed local skin reactions, 10%, constitutional symptoms, and 0.5%, anaphylaxis. Of 116 persons receiving postexposure therapy, 100% had local reactions, 33%, constitutional symptoms, and 0.9%, anaphylaxis. Thus, although duck embryo rabies vaccine is associated with a high incidence of minor reactions, it rarely causes serious difficulty and can be safely used in rabies prophylaxis.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.