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Multiple Myeloma and Benign Monoclonal Gammopathy: Differentiation by Immunofluorescence of Lymphocytes

[+] Article and Author Information

Grant support: AM 13690-04 and AM 13824-04, U.S. Public Health Service; and a grant from the New Mexico Arthritis Foundation.

▸Requests for reprints should be addressed to Ralph C. Williams, Jr., M.D., 5th floor, Department of Medicine, Bernalillo County Medical Center, Albuquerque, NM 87106.

Albuquerque, New Mexico

Ann Intern Med. 1973;78(6):837-844. doi:10.7326/0003-4819-78-6-837
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The proportions of T and B cells among peripheral blood lymphocytes were studied in 46 patients with plasma cell myeloma and in 14 patients with benign monoclonal gammopathy. Significant lowering (P < 0.001) of percentages of B cells having normal surface Ig was found in the myeloma group, whereas the patients with benign M-components showed normal proportions of B cells. Mean percentage of total B cells in myeloma patients was 10.3% ± 6.9%, whereas mean B-cell value in benign monoclonal gammopathy was 21.4% ± 11.7%. Normal B-cell values were 22.9% ± 7.1%. Myeloma patients in remission tended to have normal proportions of B cells. Individually specific or idiotypic M-component antigenic Ig markers were present in relatively high percentages in peripheral blood lymphocytes from two patients with myeloma, whereas the reverse was true in a patient with a benign M-component. There was some overlap in total B-cell values between patients with established myeloma and those with benign monoclonal gammopathy.





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