0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Multiple Myeloma and Benign Monoclonal Gammopathy: Differentiation by Immunofluorescence of Lymphocytes

FOLKE D. LINDSTRÖM, M.D.; WILLIAM R. HARDY, M.D.; BETTY J. EBERLE, Ph.D.; and RALPH C. WILLIAMS JR., M.D.
[+] Article and Author Information

Grant support: AM 13690-04 and AM 13824-04, U.S. Public Health Service; and a grant from the New Mexico Arthritis Foundation.

▸Requests for reprints should be addressed to Ralph C. Williams, Jr., M.D., 5th floor, Department of Medicine, Bernalillo County Medical Center, Albuquerque, NM 87106.


Albuquerque, New Mexico


Ann Intern Med. 1973;78(6):837-844. doi:10.7326/0003-4819-78-6-837
Text Size: A A A

The proportions of T and B cells among peripheral blood lymphocytes were studied in 46 patients with plasma cell myeloma and in 14 patients with benign monoclonal gammopathy. Significant lowering (P < 0.001) of percentages of B cells having normal surface Ig was found in the myeloma group, whereas the patients with benign M-components showed normal proportions of B cells. Mean percentage of total B cells in myeloma patients was 10.3% ± 6.9%, whereas mean B-cell value in benign monoclonal gammopathy was 21.4% ± 11.7%. Normal B-cell values were 22.9% ± 7.1%. Myeloma patients in remission tended to have normal proportions of B cells. Individually specific or idiotypic M-component antigenic Ig markers were present in relatively high percentages in peripheral blood lymphocytes from two patients with myeloma, whereas the reverse was true in a patient with a benign M-component. There was some overlap in total B-cell values between patients with established myeloma and those with benign monoclonal gammopathy.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)