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Cromolyn Prophylaxis for Chronic Asthma

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Rush Medical Center, Chicago, Illinois

Ann Intern Med. 1973;78(6):966. doi:10.7326/0003-4819-78-6-966
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Since 1965 cromolyn sodium* has been subjected to extensive pharmacological and clinical investigation in animals and man. The drug has no intrinsic bronchodilator, antihistaminic, or steroid-like properties. It appears to act by protecting the mast cell membrane and inhibiting the release of spasmogenic mediators that occur during antigen-antibody reactions and when triggered by certain seemingly nonimmunological mechanisms, such as exercise or hyperventilation (1).

In the treatment of asthma, cromolyn sodium is given by inhalation, by a capsule containing 20 mg of drug per dose, in a special turbo-inhaler device, the Spinhaler. A recent study has further clarified the fate of


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