The full content of Annals is available to subscribers

Subscribe/Learn More  >
Reviews |

Migrant Populations and the Diffusion of the Sickle-Cell Gene

[+] Article, Author, and Disclosure Information

▸Requests for reprints should be addressed to A. P. Gelpi, M.D., Palo Alto Medical Clinic, 300 Homer Ave., Palo Alto, CA 94301.

Ann Intern Med. 1973;79(2):258-264. doi:10.7326/0003-4819-79-2-258
Text Size: A A A

If we assume that the sickle-cell mutation occurred in equatorial Africa, distribution of the sickle-cell trait in the Middle East and India correlates well with historical evidence of population displacement into these areas as a result of the East African slave trade, and with the distribution of African blood group markers in Asia. The occurrence of the sickle-cell trait in southern Europe parallels the extent of the medieval Arab conquests and is believed to reflect gene flow from the Middle East. Changing endemicity of Plasmodium falciparum malaria; interaction between hemoglobin S, thalassemia, and glucose-6-phosphate dehydrogenase deficiency; and contribution to the gene pool from subjects with mild homozygous sickle-cell disease are thought to be additional reasons for patterns of sickle-cell trait distribution in Eurasian populations.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.