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Prostaglandins: Therapy for Peptic Ulcer?

Ann Intern Med. 1973;79(2):269-270. doi:10.7326/0003-4819-79-2-269
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Some of the actions of prostaglandins were first described more than 40 years ago (1); the term "prostaglandin" was coined by von Euler more than 30 years ago (2). These compounds are biologically active, cyclic fatty acids that are ubiquitous in most animal tissues. A recent resurgence of interest in these compounds, no doubt largely because of the discovery and definition of the "second messenger," cyclic adenosine 3′,5′-monophosphate (cyclic AMP), has resulted in a great many reports, published throughout the world, about the chemistry and actions of prostaglandins. Within the past 6 years the gastric antisecretory effects of several of


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