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Peritoneal Dialysis with Fructose Dialysate: Prevention of Hyperglycemia and Hyperosmolality

RASIB M. RAJA, M.D.; MARK S. KRAMER, M.D.; RAMESH MANCHANDA, M.D.; NESTOR LAZARO, M.D.; and JERRY L. ROSENBAUM, M.D., F.A.C.P.
[+] Article and Author Information

Supported in part by the Women's League for Medical Research.

▸Requests for reprints should be addressed to Rasib M. Raja, M.D., Department of Medicine, Albert Einstein Medical Center, Philadelphia, PA 19141.


Philadelphia, Pennsylvania


Ann Intern Med. 1973;79(4):511-517. doi:10.7326/0003-4819-79-4-511
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The effects of a 7% fructose solution were compared with those of a 7% dextrose solution, both with 120 meq/litre sodium, during four consecutive exchanges in 14 patients. The increase in blood total reducing substance and serum osmolality was significantly less marked with fructose than dextrose solution. There was no increase in serum sodium concentration. Three diabetic patients tolerated 48-hour peritoneal dialysis with a 1.5% fructose solution containing 140 meq/litre sodium. Blood total reducing substances did not exceed 250 mg/100 ml. There was no increase in blood uric acid concentration or decrease in venous blood pH. The peritoneal absorption of fructose was similar to that of glucose. A fructose dialysis solution may be indicated for diabetic patients and those who develop a hyperglycemic and hyperosmotic condition with dextrose solutions.

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