The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Pseudomonas aeruginosa Vaccine in Cancer Patients

[+] Article, Author, and Disclosure Information

Grant support: Clinical Grant No. 26, American Cancer Society; Special Post-doctoral Research Fellowship 1-FOS-A1 43766-01, National Institute of Allergy and Infectious Diseases (to Dr. Young); and Clinical Research Training Grant CA-05110-09, National Cancer Institute (to Dr. Meyer).

Presented in part 2 May 1970, the National Meeting of the American Federation for Clinical Research; 2 May 1971, the 63rd Annual Meeting of the American Society for Clinical Investigation; and 27 September 1972, the Interscience Conference on Antimicrobial Agents and Chemotherapy, Atlantic City.

▸Requests for reprints should be addressed to Donald Armstrong, M.D., 444 East 68th St., New York, NY 10021.

New York, New York

Ann Intern Med. 1973;79(4):518-527. doi:10.7326/0003-4819-79-4-518
Text Size: A A A

During 1969 to 1972, 361 adult patients (176 vaccinees, 185 control patients) at a cancer center were randomized into a prospective study of the lipopolysaccharide vaccine derived from 7 serotypes of Pseudomonas aeruginosa. There were no significant differences in underlying disease, antibiotic therapy, or antineoplastic treatment between the vaccine and control groups. Fatal bacteremic pseudomonas infection occurred in 19 control subjects as opposed to in 10 vaccinees, and nonbacteremic pseudomonas infections associated with death occurred in 12 control patients and in 3 vaccinees. Protection against bacteremic death was not significant, but the mortality rate associated with pseudomonas infection was 13 out of 176 for the vaccinated group versus 31 out of 185 in the control group (P < 0.01). Fatal pseudomonas infections in both vaccine and control groups were associated with marked leukopenia, low titers of opsonizing pseudomonas antibodies, or both. As an adjunct to therapy of neoplasms, immunoprophylaxis with pseudomonas vaccine was associated with a significant but limited reduction in fatal pseudomonas infection. Vaccine administration was also accompanied by a high incidence of untoward reactions.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.