The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Hepatic Granulomatosis and Sarcoidosis

[+] Article, Author, and Disclosure Information

▸Requests for reprints should be addressed to: Harold L. Israel, M.D., Jefferson Medical College, Philadelphia, PA 19107

Philadelphia, Pennsylvania, and Washington, D.C.

Ann Intern Med. 1973;79(5):669-678. doi:10.7326/0003-4819-79-5-669
Text Size: A A A

Hepatic granulomatosis found during study of patients with unexplained fever or fatigue was in the past often attributed to tuberculosis and has recently been described as a syndrome of unknown cause. Study of 30 patients with normal chest roentgenograms and noncaseating hepatic granulomas indicates the importance of biopsies from other tissues. A diagnosis of sarcoidosis appeared justified in nine patients by the demonstration of extra-abdominal granulomas or prior hilar adenopathy. Seven patients with similar clinical features and demonstration of granulomas in spleen or abdominal lymph nodes probably had sarcoidosis, and other patients may have had this disease. The Kveim reaction, positive in only 2 of 27 patients tested, has little value in excluding sarcoidosis. Corticosteroid treatment was consistently effective in control of symptoms, but serial biopsies often showed little effect on the hepatic lesions.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.