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Hypercalcemia in Bronchogenic Carcinoma: A Prospective Study of 200 Patients

RICHARD A. BENDER, M.D.; and HEINE HANSEN, M.D.
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▸Reprint requests should be addressed to Dr. Richard A. Bender, National Cancer Institute, Bldg. 10, Room 6N-119, 9000 Rockville Pike, Bethesda, MD 20014.


Bethesda, Maryland, and Washington, D.C.


Ann Intern Med. 1974;80(2):205-208. doi:10.7326/0003-4819-80-2-205
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The relation of hypercalcemia, histologic cell type, and osseous neoplastic involvement was studied in 200 consecutive patients with untreated bronchogenic carcinoma. The overall frequency of hypercalcemia was 12.5%. Twenty-three percent of patients with epidermoid carcinoma, 12.7% with large-cell anaplastic carcinoma, 2.5% with adenocarcinoma, and none with small-cell carcinoma presented with or developed hypercalcemia. Fourteen of 25 patients (56%) with elevated calcium did not have osseous metastases. Osseous involvement was most frequently observed in patients with small-cell carcinoma (66%) and adenocarcinoma (50%). The data indicate that hypercalcemia is predominantly associated with epidermoid and large-cell anaplastic carcinoma and uncommonly associated with adenocarcinoma and small-cell carcinoma, even though the latter two cell types are most frequently associated with osseous metastases.

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