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Obstructive Lung Disease in Heterozygotes for Alpha-1 Antitrypsin Deficiency

[+] Article, Author, and Disclosure Information

Grant support: Ku215/3, Deutsche Forschungsgemeinschaft; and Landesversicherungsanstalt; Hamburg, West Germany.

▸Requests for reprints should be addressed to Friedrich Kueppers, M.D., Mayo Clinic, Rochester, MN 55901.

Hamburg, West Germany

Ann Intern Med. 1974;80(2):209-212. doi:10.7326/0003-4819-80-2-209
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Alpha-1 antitrypsin phenotypes were determined in two groups of patients with chronic obstructive lung disease and in a control group. The patients in the first group had retired from work because of this disease. The second group of patients were hospitalized with the same disease; they were, generally, more seriously ill than the patients in group 1. There was an excess of heterozygotes for one of the genes determining a deficiency of alpha-1 antitrypsin (MZ) in both groups of patients. The excess was greater in the group of hospitalized patients. These findings are consistent with the hypothesis that MZ heterozygosity is a predisposing factor to chronic obstructive lung disease.





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