0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Brief Communications |

Obstructive Lung Disease in Heterozygotes for Alpha-1 Antitrypsin Deficiency

FRIEDRICH KUEPPERS, M.D.; and AXEL DÖNHARDT, M.D.
[+] Article and Author Information

Grant support: Ku215/3, Deutsche Forschungsgemeinschaft; and Landesversicherungsanstalt; Hamburg, West Germany.

▸Requests for reprints should be addressed to Friedrich Kueppers, M.D., Mayo Clinic, Rochester, MN 55901.


Hamburg, West Germany


Ann Intern Med. 1974;80(2):209-212. doi:10.7326/0003-4819-80-2-209
Text Size: A A A

Alpha-1 antitrypsin phenotypes were determined in two groups of patients with chronic obstructive lung disease and in a control group. The patients in the first group had retired from work because of this disease. The second group of patients were hospitalized with the same disease; they were, generally, more seriously ill than the patients in group 1. There was an excess of heterozygotes for one of the genes determining a deficiency of alpha-1 antitrypsin (MZ) in both groups of patients. The excess was greater in the group of hospitalized patients. These findings are consistent with the hypothesis that MZ heterozygosity is a predisposing factor to chronic obstructive lung disease.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)