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Glucose-6-Phosphate Dehydrogenase Deficiency in Sickle-Cell Anemia: A Study in Adults

MARTIN H. STEINBERG, M.D., F.A.C.P.; and BERNARD J. DREILING, M.D., F.A.C.P.
[+] Article and Author Information

Grant support: partly supported by Veterans Administration research funds.

▸Requests for reprints should be addressed to Martin H. Steinberg, M.D., Associate Chief of Staff for Research, Veterans Administration Center, Jackson, MS 39216.


Jackson, Mississippi


Ann Intern Med. 1974;80(2):217-220. doi:10.7326/0003-4819-80-2-217
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There is evidence that the prevalence of G-6-PD deficiency is greater than would be expected in individuals with sickle-cell anemia, which suggests a survival advantage for these patients. We have studied 45 individuals with sickle-cell anemia, with methods for detecting G-6-PD deficiency in the presence of reticulocytosis, and we have found its prevalence to be similar to that of control subjects. The patients were mostly adults with mild sickle-cell disease. The differences between our findings and those reported previously may be partly owing to the nature of the populations studied. Our findings do not provide evidence that G-6-PD deficiency in adults with sickle-cell anemia gives them any advantage in survival.

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