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Glomerular Sclerosis in Adults with Nephrotic Syndrome

ROBERT MATALON, M.D., F.A.C.P.; LOIS KATZ, M.D.; GLORIA GALLO, M.D.; ELAINE WALDO, M.D.; CLAUDIA CABALUNA, M.D.; and ROBERT P. EISINGER, M.D., F.A.C.P.
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▸Requests for reprints should be addressed to Robert Matalon, M.D., Veterans Administration Hospital, 408 First Ave., New York, NY 10010.


New York, New York


Ann Intern Med. 1974;80(4):488-495. doi:10.7326/0003-4819-80-4-488
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Ten adults with the nephrotic syndrome and sterile pyuria are described. On biopsy they had varying degrees of glomerular sclerosis without proliferation. Interstitial inflammation and fibrosis and tubular atrophy were often prominent. Glomerular basement membranes stained for IgG in a uniform, linear distribution and were devoid of discrete electron-dense deposits on electron microscopy. The course of disease was generally one of insidious onset, progressive azotemia, and unresponsiveness to therapy. This form of glomerular sclerosis with linear immune deposits has not previously been described and should be considered in the differential diagnosis of steroid-resistant nephrotic syndrome in adults.

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