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Skin Immunofluorescence Studies on Lupus Erythematosus and Other Antinuclear-Antibody-Positive Diseases

JAY GROSSMAN, M.D.; MARY LOU CALLERAME, M.D.; and JOHN J. CONDEMI, M.D., F.A.C.P.
[+] Article and Author Information

Grant support: training grant AI-00028, and service research grant RR-00044, U.S. Public Health Service, Washington, D.C.

Presented in part 15 October 1971 at the Upstate New York Regional Meeting of the American College of Physicians.

▸Requests for reprints should be addressed to Jay Grossman, M.D., Allergy-Immunology Service, William Beaumont Army Medical Center, El Paso, TX 79920.


Rochester, New York


Ann Intern Med. 1974;80(4):496-500. doi:10.7326/0003-4819-80-4-496
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The deposition of gamma globulins and complement at the dermal-epidermal (D-E) junction of normal-appearing skin was found by direct immunofluorescence in 54% of patients with systemic lupus erythematosus and in only one patient with procainamide-induced lupus. No patients with rheumatoid arthritis or other antinuclear-antibody-positive connective tissue diseases showed this deposition. The D-E junction staining was found only in patients with clinically active systemic lupus erythematosus, but it could not be correlated with specific organ system involvement.

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