The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Diagnostic Use of Glucagon-Induced Insulin Response: Studies in Patients with Insulinoma or Other Hypoglycemic Conditions

[+] Article, Author, and Disclosure Information

▸Address reprint requests to Leona V. Miller, M.D., Chief, Diabetes Section, Los Angeles County University of Southern California Medical Center, Los Angeles, CA 90033.

Los Angeles, California

Ann Intern Med. 1974;80(6):697-701. doi:10.7326/0003-4819-80-6-697
Text Size: A A A

The intravenous glucagon stimulation test was assessed as a diagnostic tool in the differential diagnosis of hypoglycemia. Six of seven patients with insulinoma had peak insulin values over 130 µU/ml. None of the controls with normal weight or patients with hypoglycemia as a result of other causes had a peak insulin value over 98 µU/ml. In this study and in glucagon tests done by other investigators, the peak insulin responses occurred from 3 to 30 minutes after injection of glucagon. Since this peak is highly transient it may be missed unless sampling is done every 5 minutes for at least 30 minutes. When done properly, this test was positive in over 80% of insulinoma patients. False-negative results occur in patients treated with diazoxide, hydrochlorothiazide, or diphenylhydantoin. False-positive tests may be seen in individuals who are obese or treated with tolbutamide.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.