0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Original Research |

Immunoglobulins in Temporal Arteries: An Immunofluorescent Study

GEORGE C. LIANG, M.D.; PETER A. SIMKIN, M.D.; and MART MANNIK, M.D.
[+] Article and Author Information

Grant support: training grant AM5602, National Institute of Arthritis and Metabolic Diseases; grant RR37, National Institutes of Health; and an Arthritis Clinical Research Center grant, Arthritis Foundation.

▸Requests for reprints should be addressed to Peter A. Simkin, M.D., Division of Rheumatology, Department of Medicine, School of Medicine, Seattle, WA 98195.


Seattle, Washington


Ann Intern Med. 1974;81(1):19-24. doi:10.7326/0003-4819-81-1-19
Text Size: A A A

Immunofluorescent studies were done on 15 consecutive temporal artery biopsy specimens and on control specimens obtained from 10 patients after they died from unrelated diseases. Four different patterns of immunoglobulin deposition were seen. "Cytoplasmic" and "elastic" patterns occurred together only in three patients with histologic giant cell arteritis; these patterns were not seen in control specimens. "Nuclear" deposition was seen in three patients who had circulating antinuclear antibodies. The "linear" pattern was nonspecific, because it was found in both patient and control specimens. These findings parallel those of other forms of vasculitis, which suggests that antibodies participate in the pathogenesis of giant cell arteritis. The immunoglobulins in these vessels may be antibodies to a component of the arterial wall (presumably elastin), or they may result from deposition of circulating immune complexes.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Topic Collections
PubMed Articles

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)