The full content of Annals is available to subscribers

Subscribe/Learn More  >
Brief Communications |

Erythrocyte Fragmentation in Defibrination Syndromes

[+] Article, Author, and Disclosure Information

Presented in part 15 April 1970 at the Annual Session of the American College of Physicians, Philadelphia, Pennsylvania.

▸Requests for reprints should be addressed to Dr. R. J. Jacobson, Department of Medicine, New Medical School, Esselen St., Hillbrow, Johannesburg, South Africa.

Ann Intern Med. 1974;81(2):207-209. doi:10.7326/0003-4819-81-2-207
Text Size: A A A

The morphologic features of microangiopathic hemolytic anemia were assessed retrospectively in the peripheral blood of 40 patients with defibrination syndromes associated with various clinical conditions. All patients had hypofibrinogenemia, and all but six had thrombocytopenia. Seventeen of the 40 patients had fragmented erythrocytes in their peripheral blood in association with the episode of defibrination. The presence or absence of erythrocyte fragmentation did not correlate with the degree of hypofibrinogenemia or thrombocytopenia, nor with the duration of the coagulopathy. The microangiopathic changes in the peripheral blood, especially the more severe changes, were associated with fibrin occlusion to small blood vessels and significant organ damage.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Journal Club
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.