0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Brief Communications |

Interaction of Sodium Warfarin and Rifampin: Studies in Man

ROBERT A. O'REILLY, M.D., F.A.C.P.
[+] Article and Author Information

Grant support: grant HL 8058-11, National Institutes of Health.

▸Requests for reprints should be addressed to Robert A. O'Reilly, M.D., Department of Medicine, Santa Clara Valley Medical Center, 751 South Bascom Ave., San Jose, CA 95128.


Ann Intern Med. 1974;81(3):337-340. doi:10.7326/0003-4819-81-3-337
Text Size: A A A

To evaluate the mechanism of the decrease in the hypoprothrombinemia of warfarin therapy induced by rifampin, single doses of warfarin were administered orally as well as intravenously to 10 normal subjects. Rifampin therapy in the usual dosage, 600 mg a day orally, was started 3 days before the warfarin dose and continued for the duration of the hypoprothrombinemia. We found a highly significant decrease in both the mean area of the one-stage prothrombin time (P < 0.001) and the mean area of warfarin in plasma (P < 0.001), in comparison with the effects of warfarin alone administered by the same route. These data rule out any significant effect of rifampin on the gastrointestinal absorption of the anticoagulant and suggest that the antibiotic enhances the elimination of warfarin from the body.

Topics

warfarin ; rifampin ; sodium

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)