The full content of Annals is available to subscribers

Subscribe/Learn More  >
Original Research |

Clindamycin-Associated Colitis: A Prospective Study

[+] Article, Author, and Disclosure Information

Grant support: grants AM-05280 and AM-14038, U. S. Public Health Service; and from the Upjohn Co., Kalamazoo, Michigan.

▸Requests for reprints should be addressed to Francis J. Tedesco, M.D., Division of Gastroenterology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110.

St. Louis, Missouri

Ann Intern Med. 1974;81(4):429-433. doi:10.7326/0003-4819-81-4-429
Text Size: A A A

A prospective study of 200 consecutive patients receiving clindamycin (Cleocin HCl®*) for various reasons showed a 21% incidence of diarrhea and a 10% incidence of pseudomembranous colitis. The total dosage of clindamycin before the onset of diarrhea and the clinical syndrome associated with the diarrhea were of little help in differentiating those patients with or without pseudomembranous colitis. Pseudomembranous colitis developed most frequently after orally administered clindamycin, but was also seen with clindamycin parenterally administered. Early proctoscopic examination is necessary to diagnose colitis and is the most accurate means of detecting pseudomembranes; rectal biopsy results can confirm the diagnosis and delineate the degree of inflammation present. When the diagnosis is made soon after the onset of diarrhea, and the antibiotic is stopped, the pseudomembranous colitis seems to be self-limiting with no mortality.


clindamycin ; colitis





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Journal Club
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.