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Platelet Function and Coagulation Profile in Lupus Erythematosus: Studies in 50 Patients

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Grant support: grant AM 05094, U.S. Public Health Service (Martha Regan); and grant 3336-04, Heart and Lung Institute.

▸Requests for reprints should be addressed to Dr. Simon Karpatkin, New York University Medical School, 550 First Ave., New York, NY 10016.

New York, New York

Ann Intern Med. 1974;81(4):462-468. doi:10.7326/0003-4819-81-4-462
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Platelet function and coagulation profile were examined in 50 patients with systemic lupus erythematosus. A qualitative platelet defect was found in 12 of 21 consecutive patients tested, which consisted of absent collagen-induced aggregation and impaired ADP- and epinephrine-induced aggregation (nonresponder group). Impaired platelet function correlated with clinical severity of disease and seemed to result from an antiplatelet function factor(s) that was (were) detectable in the serum of three of seven patients tested in the nonresponder group. None of the four patients tested in the responder group had the factor(s). The coagulation profile done in 50 patients showed a circulating anticoagulant in three patients, elevated fibrinogen degradation products in five other patients, and nonspecific isolated abnormal findings in seven patients. Two of the circulating anticoagulants were identified as IgG and IgG + IgM immunoglobulins.





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