The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Digoxin Tablet Bioavailability: Single-Dose and Steady-State Assessment

[+] Article, Author, and Disclosure Information

Grant support: grant U-2230, Health Research Council, City of New York; HL-10608, National Institutes of Health; 72-853, American Heart Association; and grants from the Burroughs Wellcome Co., the New York Heart Association, and the World Health Organization. Dr. Preibisz was a Visiting Fellow of the World Health Organization. Dr. Butler is the recipient of an Irma T. Hirschl Career Scientist Award.

▸Requests for reprints should be addressed to John Lindenbaum, M.D., Medical Service, Harlem Hospital Center, Lenox Ave. and 135th St., New York, NY 10037.

New York, New York

Ann Intern Med. 1974;81(4):469-474. doi:10.7326/0003-4819-81-4-469
Text Size: A A A

Variation in the biological availability of digoxin tablets is a significant problem, and the relative accuracy and reliability of various methods of assessing absorption of the glycoside have not been established. In a crossover study, the bioavailability of four lots of digoxin tablets with different dissolution rates was tested in seven normal volunteers after single 0.5-mg doses and 0.5-mg doses were given daily for 9 days. Digoxin preparations that showed marked differences after single doses also showed significant differences by the "steady-state" measurements. Two lots of digoxin from the same manufacturer showed major discrepancies. The single-dose measurements used (peak serum levels, areas under the concentration-time curves, and 24-hour urinary digoxin excretion) did not reliably predict the magnitude of differences found in the steady state when drug products with different rates of absorption were compared. Of the three single-dose measurements, the 24-hour urinary excretion level seemed to be the most reliable screening test.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Journal Club
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.