The full content of Annals is available to subscribers

Subscribe/Learn More  >
Original Research |

Adriamycin Cardiotoxicity in Man

[+] Article, Author, and Disclosure Information

Grant support: grants CA-04920-14 and CA-05192-06 from the National Institutes of Health, U.S. Public Health Service and grant CF 3032 from the American Cancer Society.

Presented in part in April 1973 at the National Meeting of the American Federation of Clinical Research.

▸Requests for reprints should be addressed to Stanley P. Balcerzak, M.D., Ohio State University Hospital, 410 West 10th Ave., Columbus, OH 43210.

Columbus, Ohio

Ann Intern Med. 1974;81(4):475-478. doi:10.7326/0003-4819-81-4-475
Text Size: A A A

Noninvasive methods to detect early adriamycin-induced cardiac injury and to follow the course of the injury were prospectively studied. Serial physical examinations, chest X rays, electrocardiograms (ECG), and systolic time interval measurements were done. The pre-ejection period to left ventricular ejection time (PEP/LVET) ratio increased in eight of nine patients receiving a cumulative dose of 310 to 540 mg/m2 body surface area of adriamycin. Heart size increased in only two of these patients, and ECG changed in only one. PEP/LVET ratios improved 2 to 6 months after cessation of therapy. Persistently abnormal ratios improved in three of four patients after treatment with digoxin. Patients receiving a cumulative dose of 56 to 290 mg/m2 body surface area of adriamycin showed transient worsening of PEP/LVET ratios that returned to normal by 1 month after therapy. Patients receiving other chemotherapeutic agents had no increase in PEP/LVET ratios. Systolic time interval measurements are valuable in detecting early cardiotoxicity and in reducing the risk of life-threatening heart failure in patients receiving adriamycin.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.