The full content of Annals is available to subscribers

Subscribe/Learn More  >
Diagnosis and Treatment |

Drugs Five Years Later: Dextran 40

[+] Article, Author, and Disclosure Information

▸Requests for reprints should be addressed to Alan S. Nies, M.D., Department of Medicine and Pharmacology, School of Medicine, Vanderbilt University, Nashville, TN 37232.

Nashville, Tennessee

Ann Intern Med. 1974;81(4):500-504. doi:10.7326/0003-4819-81-4-500
Text Size: A A A

Dextran 40 has been approved for use as a volume expander for shock of any cause and as a pump primer for extracorporeal circulation. Since its approval, no critical studies that clearly show its superiority over other solutions have been published. It is being used increasingly for prophylactic antithrombotic therapy in surgical patients who are at high risk of thromboembolic complications, and comparative studies show it to be as effective as warfarin for this purpose. But its dangerous and potentially fatal side effects should be known to the potential user. These include anaphylaxis and other allergic reactions, hypervolemia, renal failure, and a bleeding diathesis. These side effects may be overlooked because they can be easily ascribed to the condition for which the drug is being given. Because other equally effective drugs are available for all the approved uses of dextran 40, we cannot recommend this drug until we have comparative data that establish it as being at least as safe and effective as the alternatives.







Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.