0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Brief Communications |

Intestinal Manifestations of Fabry's Disease

JOHN W. ROWE, M.D.; JULIAN I. GILLIAM, M.D.; and THOMAS A. WARTHIN, M.D., M.A.C.P.
[+] Article and Author Information

Grant support: U.S. Public Health Service grants HD05515 and N. S. 10330.

▸Address reprint requests to Dr. Warthin, Chief, Medical Service, West Roxbury Veterans Administration Hospital, West Roxbury, MA 02132.


West Roxbury and Boston, Massachusetts


Ann Intern Med. 1974;81(5):628-631. doi:10.7326/0003-4819-81-5-628
Text Size: A A A

Four adult patients with Fabry's disease had intestinal involvement. One was asymptomatic, and three suffered from episodic diarrhea. In one patient, diarrhea was the only clinical manifestation of Fabry's disease. Radiologic studies revealed similar changes in the small and large bowels of all four patients. Small bowel changes consisted of thickening of folds and mild dilatation throughout and the presence of an unusual granular appearance of the ileum. Barium enemas showed loss of the colonic haustral markings, particularly in the more distal colonic segments. Serial studies on the symptomatic patients, before and after the onset of diarrhea, showed progression of the radiographic changes. There was no evidence of malabsorption or gastrointestinal blood loss in any of the patients. Intestinal involvement may be common in Fabry's disease.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Topic Collections
PubMed Articles

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)