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Outpatient Treatment of Paget's Disease of Bone with Mithramycin

DENNIS LEBBIN, M.D.; WILL G. RYAN, M.D., F.A.C.P.; and THEODORE B. SCHWARTZ, M.D., F.A.C.P.
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▸Address reprint requests to W. G. Ryan, M.D., 1753 West Congress Parkway, Chicago, IL 60612.


Chicago, Illinois


Ann Intern Med. 1974;81(5):635-637. doi:10.7326/0003-4819-81-5-635
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Mithramycin is a cytotoxic antibiotic that causes hypocalcemia and diminishes the elevated osteoclastic activity characteristic of Paget's disease. Previous inpatient studies have shown that this drug causes striking clinical and biochemical improvement in patients with severe widespread disease. To simplify therapy and lessen toxicity, 13 patients with this form of Paget's disease were treated for 1 to 14 months with either of two different outpatient regimens. During therapy the elevation in the serum alkaline phosphatase decreased by 40% to 99%, and all patients reported symptomatic improvement. Manifestations of toxicity were mild and transient.

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