The full content of Annals is available to subscribers

Subscribe/Learn More  >
Brief Communications |

Narcotic Withdrawal Syndrome Caused by Naltrexone

[+] Article, Author, and Disclosure Information

▸Requests for reprints should be addressed to Vincent Tornabene, M.D., Department of Medicine, Harlem Hospital Center, 135th and Lenox Ave., New York, NY 10037.

New York, New York

Ann Intern Med. 1974;81(6):785-787. doi:10.7326/0003-4819-81-6-785
Text Size: A A A

Three persons who were regularly taking methadone, heroin, or both, ingested 50 to 188 mg of naltrexone, a potent narcotic antagonist. Each experienced an acute narcotic withdrawal syndrome beginning within 5 minutes of ingestion and lasting up to 48 hours. Mental status changes including confusion and somnolence were noted in two patients, one of whom also experienced visual hallucinations. Significant fluid loss through vomiting and diarrhea, which required intravenous fluid replacement, occurred in the same two patients. Illicit dissemination of naltrexone poses another hazard for opiate addicts.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Journal Club
Topic Collections
PubMed Articles
Opioid Use Disorders. Child Adolesc Psychiatr Clin N Am 2016;25(3):473-87.
Management of impulse control disorders in Parkinson's disease. Int Psychogeriatr Published online Jul 4, 2016;
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.