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Pregnancy After Renal Transplantation

Ann Intern Med. 1975;82(1):113-114. doi:10.7326/0003-4819-82-1-113
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Renal failure induces hypogonadotrophic hypogonadism; when the endogenous creatinine clearance decreases in women to 4 ml/min, menses cease (1). The hypothalamic suppression accompanying uremia exemplifies a functional interdependence that ensures infertility in patients whose survival is threatened. Renal transplantation saves life and restores renal function; return of gonadotrophin secretion follows. The incidental return of fertility potential poses significant problems: patients who desire to become parents have a decreased life expectancy and may be chronically ill; female recipients and their fetuses face complications uniquely associated with pregnancy.

One hundred thirty-six pregnancies after renal transplantation are recorded in the admittedly incomplete files of


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