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Low Platelet Adhesiveness and Other Hemostatic Abnormalities in Hypothyroidism

J. ROGER EDSON, M.D.; DENNIS R. FECHER, M.D.; and RICHARD P. DOE, M.D., Ph.D.
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▸ Requests for reprints should be addressed to Dr. Edson, Department of Laboratory Medicine and Pathology, Box 198 Mayo Memorial Building, University of Minnesota School of Medicine, Minneapolis, MN 55455.


Minneapolis, Minnesota, and Fort Smith, Arkansas


Ann Intern Med. 1975;82(3):342-346. doi:10.7326/0003-4819-82-3-342
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Fifteen patients with definite hypothyroidism and two with probable hypothyroidism had extensive hemostatic profiles done. In 12 of the 16 patients tested, the platelet adhesiveness (platelet retention in a glass bead column) was abnormal, and in 1 more it was borderline. In the six patients who were studied repeatedly, hemostatic abnormalities either markedly improved or disappeared after treatment with L-thyroxine. It is concluded that, in addition to the previously reported coagulation factor deficiencies (which we also observed in some of our patients), low platelet adhesiveness occurs frequently in patients with hypothyroidism.

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