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Hyperglucagonemia in Uremia: Reversal by Renal Transplantation

GORDON L. BILBREY, M.D.; GERALD R. FALOONA, Ph.D.; MARTIN G. WHITE, M.D.; CAROLYN ATKINS, R.N.; ALAN R. HULL, M.D.; and JAMES P. KNOCHEL, M.D.
[+] Article and Author Information

Grant support: grant PO1 HE11 662 from the U.S. Public Health Service, Veterans Administration, The Hoechst Pharmaceutical Co., Upjohn Pharmaceutical Co., and the Dallas Diabetes Association.

▸Requests for reprints should be addressed to James P. Knochel, M.D., Veterans Administration Hospital, 4500 S. Lancaster Rd., Dallas, TX 75216.


Dallas, Texas


Ann Intern Med. 1975;82(4):525-528. doi:10.7326/0003-4819-82-4-525
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Chronic renal failure in man is associated with hyperglucagonemia that is not corrected by hemodialysis. Plasma glucagon concentrations were measured in nine patients before and after renal transplantation. Mean plasma glucagon concentration in eight patients with chronic renal failure before transplantation was 295 ± 171 pg/ml (± SD). After successful transplantation, mean plasma glucagon concentration fell to 134 ± 81 pg/ml (± SD) (P < 0.001). Plasma glucagon concentration remained elevated in an additional patient who received a cadaveric graft that never functioned. Immunologic rejection of transplanted kidneys was associated with a dramatic increase of plasma glucagon concentration.

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